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Michael E DiSanto Selected Research

blebbistatin

1/2021Changes in the expression and functional activities of Myosin II isoforms in human hyperplastic prostate.
10/2018Blebbistatin modulates prostatic cell growth and contrapctility through myosin II signaling.
1/2012Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetes.
1/2011In vitro and in vivo relaxation of urinary bladder smooth muscle by the selective myosin II inhibitor, blebbistatin.
1/2011Blebbistain, a myosin II inhibitor, as a novel strategy to regulate detrusor contractility in a rat model of partial bladder outlet obstruction.

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Michael E DiSanto Research Topics

Disease

7Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
10/2023 - 01/2018
5Neoplasms (Cancer)
01/2024 - 01/2021
5Urinary Bladder Neck Obstruction (Bladder Neck Obstruction)
11/2020 - 06/2002
4Fibrosis (Cirrhosis)
02/2024 - 03/2023
4Blister (Bulla)
01/2021 - 01/2011
3Hypertrophy
11/2020 - 02/2006
2Hyperplasia
02/2023 - 01/2021
2Inflammation (Inflammations)
02/2023 - 01/2019
2Lower Urinary Tract Symptoms
01/2021 - 11/2020
2Overactive Urinary Bladder (Overactive Bladder)
10/2012 - 01/2011
1Nocturia
03/2023
1Pathologic Processes
02/2023
1Prostatic Neoplasms (Prostate Cancer)
09/2022
1Breast Neoplasms (Breast Cancer)
08/2021
1Urologic Diseases (Urinary Tract Disease)
01/2021
1Renal Cell Carcinoma (Grawitz Tumor)
01/2021
1Erectile Dysfunction
12/2020
1Prostatitis
01/2019
1Hyperlipidemias (Hyperlipidemia)
12/2015
1Urethral Obstruction
10/2012
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2012

Drug/Important Bio-Agent (IBA)

7Protein Isoforms (Isoforms)IBA
10/2018 - 06/2002
6Myosins (Myosin)IBA
10/2018 - 06/2002
5blebbistatinIBA
01/2021 - 01/2011
4Myosin Type IIIBA
01/2021 - 01/2011
4Proteins (Proteins, Gene)FDA Link
10/2018 - 06/2002
3CateninsIBA
02/2024 - 03/2023
3Phenylephrine (Neo-Synephrine)FDA LinkGeneric
01/2021 - 06/2002
3salicylhydroxamic acid (SHAM)IBA
10/2012 - 06/2002
2Biomarkers (Surrogate Marker)IBA
01/2024 - 01/2021
2Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
12/2020 - 11/2020
2Carbachol (Carbastat)FDA Link
11/2020 - 01/2011
1S100 Calcium-Binding Protein A4IBA
02/2024
1Calcium-Binding ProteinsIBA
02/2024
1AntigensIBA
01/2024
1CollagenIBA
01/2024
1Y 27632IBA
10/2023
1Simvastatin (Zocor)FDA LinkGeneric
03/2023
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
03/2023
1Cell Adhesion MoleculesIBA
02/2023
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
02/2023
1Cadherins (E-Cadherin)IBA
02/2023
1IntegrinsIBA
02/2023
17-dehydrocholesterol reductaseIBA
01/2023
1EnzymesIBA
01/2023
1SterolsIBA
01/2023
1HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
09/2022
1Heat-Shock Proteins (Heat-Shock Protein)IBA
09/2022
1Bone Morphogenetic Protein 5IBA
12/2021
1Insulin-Like PeptidesIBA
01/2021
1RNA (Ribonucleic Acid)IBA
01/2021
1Epidermal Growth Factor (EGF)IBA
01/2021
1Phosphodiesterase 5 InhibitorsIBA
11/2020
1Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
11/2020
1InterleukinsIBA
01/2019
1LipopolysaccharidesIBA
01/2019
1Interleukin-21 ReceptorsIBA
01/2019
1Caspase 3 (Caspase-3)IBA
10/2018
1AndrogensIBA
01/2018
1Testosterone (Sustanon)FDA Link
12/2015
1Advanced Glycation End ProductsIBA
12/2015
1Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2015
1Hormones (Hormone)IBA
12/2015
1CalciumIBA
10/2012
1PotassiumIBA
10/2012
1Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA
10/2012
1Streptozocin (Streptozotocin)FDA Link
01/2012
1Muscarinic AntagonistsIBA
01/2011
1CalcineurinIBA
09/2006
1Atrial Natriuretic Factor (ANF)IBA
09/2006
1Cyclosporine (Ciclosporin)FDA LinkGeneric
09/2006
1Adenosine Triphosphatases (ATPase)IBA
06/2002
1Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)IBA
06/2002
1Messenger RNA (mRNA)IBA
06/2002
1polyacrylamideIBA
06/2002

Therapy/Procedure

2Drug Therapy (Chemotherapy)
08/2021 - 01/2012
1Mammaplasty (Breast Reconstruction)
08/2021
1Therapeutics
01/2011